Therapeutics

Therapeutics are the cornerstone of healthcare. WRCB has funded several projects in therapeutics including wound healing, drug delivery using liposomal, micro- and nano-encapsulations, dialysis systems, and drug discovery for diseases such as tuberculosis, triple-negative breast cancer, Acute Respiratory Disease Syndrome, Diabetes, etc. Here is a list of therapeutics projects supported by WRCB.
IITB-CMU Call

Determining the effect of liposomal molecular structure on immune response

Developed By

Rahul Purwar, Kathryn Whitehead

Department

Biosciences and Bioengineering, Carnegie-Mellon University

9th Call

Establishment of polymeric implant for localised and sustained delivery of Gemcitabine and Curcumin for management of pancreatic cancer

Developed By

Rajdip Bandyopadhyaya

Department

Chemical Engineering

9th Call

Development of mammalian host cell lines for rapid production of recombinant proteins

Developed By

Sarika Mehra

Department

Chemical Engg

9th Call

CRISPR Derived Stem Cells and Exosomes As Nanotherapeutics for Spinal Muscular Atrophy Category

Developed By

Sreelaja Nair

Department

Biosciences and Bioengineering

9th Call

Development of Dual Drug Liraglutide and Myricetin encapsulated oral chitosan nanosuspension for the management of Type II Diabetes (T2DM)

Developed By

Ashutosh Kumar

Department

Biosciences and Bioengineering

8th Call

Bioactive GelMA-chitosan wound dressings for diabetic wound healing

Developed By

Shamik Sen

Department

Biosciences and Bioengineering

8th Call

Optimization and validation of a microfluidics- based static gradient generator for drug screening and drug discovery

Developed By

Abhijit Majumder, Prasanna Gandhi

Department

Chemical Engineering, Mechanical Engineering

View Project
8th Call

Sustained release of bioactive insulin using amyloid hydrogel for the treatment of type II diabetes

Developed By

Samir Maji

Department

Biosciences and Bioengineering

View Project
6th Call

Development of nanoparticles loaded in-situ gels as regional vaginal, uterine and pelvic depots for treatment of endometriosis

Developed By

Rinti Banerjee

Department

Biosciences and Bioengineering

View Project
6th Call

Development of efficient bioprocesses for the PEGylation of therapeutic proteins

Developed By

Pramod Wangikar

Department

Chemical Engineering

View Project
5th call

Use of Graphene Quantum dot-Peptide-DOX conjugate for targeted therapy of ovarian cancer

Developed By

Prof. Sudhanshu Mallick

Department

Metallurgical Engineering and Material Science

View Project
5th Call

Synthesis of specific water-soluble NIR fluorophores and their applications in cancer research.

Developed By

M. Ravikanth

Department

Chemistry

View Project
4th Call

Development of a cell culture system that will facilitate expansion of human Mesenchymal Stem Cells without sacrificing their stemness

Developed By

Abhijit Majumder

Department

Chemical Engineering

4th Call

Understanding the metabolic reprogramming linked with (dys)regulation of islet amyloid polypeptide (IAPP) expression in Type 2 Diabetes mellitus (T2DM)

Developed By

Ashutosh Kumar

Department

Biosciences and Bioengineering

4th Call

Evaluation of the anti-pneumococcal potential of BT-Benzo-29

Developed By

Dulal Panda

Department

Biosciences and Bioengineering

4th Call

Drug-nanoparticle-polymer conjugate as a platform for targeted treatment of pancreatic cancer

Developed By

Rajdip Bandyopadhyaya

Department

Chemical Engineering

4th Call

Design of PNA-based adjuvants in tuberculosis therapy.

Developed By

Sarika Mehra

Department

Chemical Engineering

4th Call

Bioactive GelMA hydrogels for diabetic wound healing

Developed By

Shamik Sen

Department

Biosciences and Bioengineering

4th Call

Towards Molecularly Complete Membrane Scaffolds for "cell-free" drug screening in tuberculosis

Developed By

Shobhna Kapoor

Department

Chemistry

4th Call

Droplet microfluidic platform for cell encapsulation

Developed By

Venkat Gundabala

Department

Chemical Engineering

3rd Call

Drug-loaded surfactants for acute lung injury and acute respiratory distress syndrome (ARDS)

Developed By

Rinti Banerjee

Department

Biosciences and Bioengineering

3rd Call

Development of novel amyloid-based hydrogels for sustained release of insulin

Developed By

Samir K. Maji

Department

Biosciences and Bioengineering

3rd Call

Evaluation of indigenously developed CAR-T platform technology for the treatment of Acute Lymphoblastic Leukemia (ALL)

Developed By

Rahul Purwar

Department

Biosciences and Bioengineering

2nd Call

Targeted polymeric nanoformulation of a microtubule inhibitor, SKG-34-12, is an attractive strategy for triple-negative breast cancer therapy

Developed By

Dulal Panda

Department

Biosciences and Bioengineering

2nd Call

Combining substrate stiffness and topography for inducing differentiation of mouse embryonic stem cells into dopaminergic neurons

Developed By

Shamik Sen, Dipti Gupta

Department

Biosciences and Bioengineering, Metallurgical Engineering and Material Science

1st Call

Development of novel amyloid-based material for drug delivery

Developed By

Samir K. Maji

Department

Biosciences and Bioengineering

1st Call

Coated nanoparticles for superior drug delivery and efficacy in overcoming tuberculosis

Developed By

Sarika Mehra, Rajdeep Bandyopadhyaya

Department

Chemical Engineering, Chemical Engineering

Development of a multipronged antibacterial candidate to treat drug-resistant bacterial infections

Developed By

Venkateswarlu Yarlagadda

Department

Bioactive cell derived matrices for generation & transplantation of functional pancreatic 𝛽 cells

Developed By

Shamik Sen

Department

Biosciences and Bioengineering

Evolution of Artificial metalloenzymes for the Chemo -photo - enzymatic asymmetric synthesis of Indolonebased drug

Developed By

Debabrata Maiti

Department

Chemistry

Therapeutic targeting of bradyzoites, the latent stages of Toxoplasma gondii, using carbon dots

Developed By

Swati Patankar

Department

Biosciences and Bioengineering

Targeting Autosomal Dominant Polycystic Kidney Disease with chemically modified Metformin

Developed By

Swapnil Rohidas Shinde

Department

Biosciences and Bioengineering

Design and development of small molecular synthetic functional mimics of bacterial cell wall lipid targeting antibiotics

Developed By

Venkateswarlu Yarlagadda

Department

Chemistry

Strategies for Expeditious Synthesis of Flavans and Study of their Biological Activity

Developed By

Santosh Gharpure

Department

Chemistry

Identification of multitarget Phytochemicals from Ganoderma Against Breast Cancer via in silico and in vitro studies

Developed By

Sushil Kumar

Department

Biosciences and Bioengineering

Development of latex-based iodinated beads (iBeads) for the treatment of Surgical Infections

Developed By

Venkata Gundabala

Department

Biosciences and Bioengineering

eRapid: Multiplexed Electrochemical Sensors for Fast, Accurate, Portable Diagnostics

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Therapeutics

Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease Diagnostics

This nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers.
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wFDCF Face Masks: A Wearable COVID-19 Diagnostic

The Problem The COVID-19 pandemic has made it starkly clear that the world lacks rapid, accurate diagnostic tests for pathogens. When patients arrive in a medical facility for treatment, the triage process is hindered by diagnostic tests that are inaccurate or take a long time to produce results
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